Cells | Free Full-Text | Lamina Associated Domains and Gene Regulation in Development and Cancer

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Open AccessReview

Oncode Institute, Hubrecht Institute–KNAW and University Medical Center Utrecht, 3584 Utrecht, The Netherlands


Author to whom correspondence should be addressed.

These authors contributed equally to this work.

Received: 28 February 2019 / Revised: 18 March 2019 / Accepted: 19 March 2019 / Published: 21 March 2019

The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization. Genomic regions contacting the NL are lamina associated domains (LADs), which contain thousands of genes that are lowly transcribed, and enriched for repressive histone modifications. LADs are dynamic structures that shift spatial positioning in accordance with cell-type specific gene expression changes during differentiation and development. Furthermore, recent studies have linked the disruption of LADs and alterations in the epigenome with the onset of diseases such as cancer. Here we focus on the role of LADs and the NL in gene regulation during development and cancer.

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MDPI and ACS Style

Lochs, S.J.A.; Kefalopoulou, S.; Kind, J. Lamina Associated Domains and Gene Regulation in Development and Cancer. Cells 2019, 8, 271.

AMA Style

Lochs SJA, Kefalopoulou S, Kind J. Lamina Associated Domains and Gene Regulation in Development and Cancer. Cells. 2019; 8(3):271.

Chicago/Turabian Style

Lochs, Silke J.A.; Kefalopoulou, Samy; Kind, Jop. 2019. “Lamina Associated Domains and Gene Regulation in Development and Cancer.” Cells 8, no. 3: 271.

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